Ethyl cyanoacetate → 2-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)acetonitrile

Participants

Reaction Steps

The product from Step 2 (500 mg, 3.6 mmole) and ethyl cyanoacetate (620 mg, 5.5 mmol) were heated together at 190° C. for 20 minutes. After cooling to room temperature, the residue was purified by column chromatography eluting with 10% methanol in ethyl acetate to afford the title compound (250 mg, 37%); MS (ES+) m/e 187 [M+H]+.

Provenance & Evidence