反应详情

To a solution of the product from Example 100 (1.5 g, 4.85 mmol) in 1,4-Dioxane (50 ml) was added 4-carboxybenzene boronic acid (1.20 g, 7.23 mmol), sodium carbonate (7 ml of a 2 M solution) and tetrakis(triphenylphosphine)palladium(0) (1.12 g, 0.97 mmol). The reaction mixture was heated to reflux with stirring for 18 hours and allowed to cool. The reaction mixture was filetered and washed with ether (5×, 100 ml) to afford the title compound as a yellow solid (0.594 g, 35%); MS (ES+) m/e 351 [M+H]+.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux
3. temperatureto cool
4. washwashed with ether (5×, 100 ml)