Boron tribromide → HCID 59681770, compound

Participants

Reaction Steps

To a solution of the product from Example 187 (0.1 g, 0.26 mmol) in anhydrous dichloromethane (10 ml) stirred at 0° C., was added dropwise boron tribromide (1.0 M solution in dichloromethane, 2.3 ml, 2.3 mmol) and the mixture stirred at room temperature for 16 hours. The reaction was quenched with water (20 ml), basified to pH 14 with 50% sodium hydroxide solution. The aqueous phase was washed with dichloromethane 3×, neutralised with 6 N hydrochloric acid, and the resulting precipitate collected, washed with water 3×, diethyl ether and dried in vacuo to yield the title product (40 mg, 40%); MS (ES+) m/e 374 [M+H]+.

Provenance & Evidence