反应详情

A solution of the product of Step 2 (950 mg, 5 mmol), sodium methoxide (695 mg, 12.5 mmol) in methanol (10 ml) was heated at reflux for 2 hours. After cooling the solvent was removed in vacuo and the residue partitioned between ethyl acetate and water. The organic phase was washed with water and brine, dried and evaporated in vacuo to give the title compound (900 mg, 98%). MS (ES+) m/e 185 [M+H]+.

1. temperatureat reflux for 2 hours
2. temperatureAfter cooling the solvent
3. customwas removed in vacuo
4. customthe residue partitioned between ethyl acetate and water
5. washThe organic phase was washed with water and brine
6. customdried
7. customevaporated in vacuo