HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 12986252, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Phenyl chloroformate | HCID 15891 | — |
| Reactant | 3-Phenylpropylamine | HCID 16259 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 12986252 | HCID 12986252 | — |
Reaction Steps
Chloroformic acid phenyl ester (3.29 g, 21.0 mmole) and pyridine (1.74 g, 22.0 mmole) were added to a solution of 3-phenylpropylamine (2.7 g, 20.0 mmole) in CH2Cl2 and stirred for 24 h at room temperature. Working up was performed by extracting the batch successively with H2O, 1M HCl and 1M NaOH. The organic phase was dried with Na2SO4 and evaporated. The product was obtained as a colorless solid (m.p. 55-56° C.) in a yield of 4.11 g (81%) by recrystallisation from ethyl acetate/hexane (1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07348354B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-96edc421ab8740dd9f68e62ddf352ccc |
| Source note | uspto-grants-2008_03 |