反应详情

The more polar diastereomer of (4-dimethylamino-4-phenyl-cyclohexyl)amine (143 mg, 0.66 mmole) and 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (272 mg, 0.98 mmole) were added to a solution of N-(3-indolylacetyl)-L-leucine (189 mg, 0.66 mmole) in MeOH and stirred for 24 h at room temperature. Working up was performed by removing MeOH by distillation. The residue was re-dissolved with water, adjusted to pH 11 with 5M NaOH and extracted with ethyl acetate. The organic phase was dried with Na2SO4 and then evaporated. The product was obtained as a colorless oil in a yield of 320 mg (100%).

1. customby removing MeOH
2. distillationby distillation
3. dissolutionThe residue was re-dissolved with water
4. extractionextracted with ethyl acetate
5. dry with materialThe organic phase was dried with Na2SO4
6. customevaporated
7. customThe product was obtained as a colorless oil in a yield of 320 mg (100%)