反应详情

Chloroformic acid phenyl ester (760 μl, 6.03 mmole) and pyridine (510 μl, 6.31 mmole) were added to a solution of 2-(1H-indol-3-yl)-1-methyl-ethylamine (1.0 g, 5.74 mmole) in abs. DCM (20 ml). Stirring was then performed for 24 h at RT. Working up was performed by extracting the batch with water (2×20 ml), with 1M HCl (2×20 ml) and with 1M NaOH (2×20 ml). The organic phase was dried with Na2SO4 and evaporated. [2-(1H-Indol-3-yl)-1-methylethyl]carbamic acid phenyl ester was obtained as a colorless solid in a yield of 1.35 g (80%).

1. extractionby extracting the batch with water (2×20 ml)
2. dry with materialThe organic phase was dried with Na2SO4
3. customevaporated