Citric Acid → HCID 86601795, compound

Participants

Reaction Conditions

Reaction Steps

In order to produce the citrate, the more polar diastereoisomer of 1-(4-dimethylamino-4-phenyl-cyclohexyl)-3-[2-(1H-indol-3-yl)-1-methyl-ethyl]-thiourea (256 mg, 0.59 mmole) was dissolved in hot ethanol (8 ml) and combined with a likewise hot solution of citric acid (249 mg, 1.3 mmole) in ethanol (1 ml). After cooling to approx. 5° C., the batch was left to stand for 4 h. The resulting solid was filtered out. The more polar diastereoisomer of 1-(4-dimethylamino-4-phenyl-cyclohexyl)-3-[2-(1H-indol-3-yl)-1-methyl-ethyl]-thiourea citrate could be obtained in this manner as a colorless solid (Example 34, melting point: 108-113° C.) in a yield of 369 mg (100%).

Provenance & Evidence