Citric Acid → HCID 86601799, compound

Participants

Reaction Conditions

Reaction Steps

In order to produce the citrate, the more polar diastereoisomer of 1-[2-(4-dimethylamino-4-phenylcyclohexyl)ethyl]-3-[2-(1H-indol-3-yl)ethyl]thiourea (330 mg, 0.71 mmole) was dissolved in hot ethanol (4 ml) and combined with a likewise hot solution of citric acid (137 mg, 0.71 mmole) in ethanol (1 ml). After cooling to approx. 5° C., the batch was left to stand for 4 h. Since no solid precipitated out, the ethanol was removed by distillation. The more polar diastereoisomer of 1-[2-(4-dimethylamino-4-phenylcyclohexyl)ethyl]-3-[2-(1H-indol-3-yl)-ethyl]thiourea citrate was obtained in this manner as a colorless foam (Example 44, melting point: 90-95° C.) in a yield of 467 mg (100%).

Provenance & Evidence