N-t-butoxycarbonyl-4-(4-fluorobenzylidene)piperidine → 4-(4-Fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

Participants

Reaction Steps

1-tert-Butoxycarbonyl-4-(4-fluorobenzylidene)piperidine (47.0 g) was dissolved in methanol (450 ml). To the solution was added 10% palladium carbon (water content: 50%, 4.7 g), and the mixture was subjected to catalytic hydrogenation reaction for 5 hours. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give 1-tert-butoxycarbonyl-4-(4-fluorobenzyl)piperidine (39.9 g).

Provenance & Evidence