Triethyl Phosphate → Methyl 4-(diethoxyphosphorylmethyl)benzoate

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-(bromomethyl)benzoate (25 g, 109 mmol) and triethyl phosphate (24.3 ml, 142 mmol) was stirred at 150° C. for 24 h. The resulting mixture was purified by distillation (165-172° C., 1 mmHg) to obtain diethyl 4-(methoxycarbonyl)benzylphosphonate (21.5 g, 69%).

Provenance & Evidence