2-Aminopyridine → N-(2-chloro-5-(trifluoromethyl)pyridin-4-yl)pyridin-2-amine
Reaction equation
[C:20](=[O:21])([O-:22])[O-:23].[Cl:1][c:2]1[n:3][cH:4][c:5]([C:9]([F:10])([F:11])[F:12])[c:6]([I:8])[cH:7]1.[Cs+:24].[Cs+:25].[NH2:13][c:14]1[n:15][cH:16][cH:17][cH:18][cH:19]1.[O:26]1[CH2:27][CH2:28][O:29][CH2:30][CH2:31]1.[O:34]=[C:35]([CH:36]=[CH:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[CH:44]=[CH:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1.[O:52]=[C:53]([CH:54]=[CH:55][c:56]1[cH:57][cH:58][cH:59][cH:60][cH:61]1)[CH:62]=[CH:63][c:64]1[cH:65][cH:66][cH:67][cH:68][cH:69]1.[O:70]=[C:71]([CH:72]=[CH:73][c:74]1[cH:75][cH:76][cH:77][cH:78][cH:79]1)[CH:80]=[CH:81][c:82]1[cH:83][cH:84][cH:85][cH:86][cH:87]1.[Pd:32].[Pd:33]>>[Cl:1][c:2]1[n:3][cH:4][c:5]([C:9]([F:10])([F:11])[F:12])[c:6]([NH:13][c:14]2[n:15][cH:16][cH:17][cH:18][cH:19]2)[cH:7]1Participants
8
Sources & evidence
- ORD record
- ord-ce0595dfbb574c2c9a4e344e5a8bdf2b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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