Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphoric Acid → Zaleplon
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphoric Acid | HCID 1004 | — |
| 반응물 | N-(3-(3-(Dimethylamino)-1-oxo-2-propenyl)phenyl)-N-ethylacetamide | HCID 53395302 | — |
| 반응물 | HCID 178510443 | HCID 178510443 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Zaleplon | HCID 5719 | 90.2% |
반응 단계
Ethylacetamide 3 (260 g, 1 mol) and 3-amino-4-cyanopyrazole 4 (108 g, 1 mol) were dissolved in a mixture of water (7 L) and ethanol (4 L). Eighty five percent aqueous phosphoric acid (67 ml, 1 mol) was added and the mixture was stirred at room temperature for 8 h. The reaction mixture was then cooled to 5° C. and the crystalline product that formed was collected, washed with water and dried at 60° C. to afford zaleplon (275 g, 90.2%) which was 99.36 pure by HPLC and contained 0.21% regioisomer 5.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07348429B2 |
| 출처 데이터셋 | uspto-grants-2008_03 |
| ORD ID | ord-439677137b274c659f937bad5d09b7e9 |
| 출처 메모 | uspto-grants-2008_03 |