Dimethylformamide → HCID 69218892, compound

Participants

Reaction Conditions

Reaction Steps

3-[3-(2-Butoxy-3,5-diisopropyl-phenyl)-1H-indol-5-yl]-but-2-enoic acid (129 mg, 0.30 mmol), cesium carbonate (293 mg, 0.90 mmol), and iodomethane (0.041 mL, 65 mmol) were combined in DMF (6 mL) and heated at 40° C. for 2 h. The reaction was diluted with water and extracted with ethyl acetate (2×). The organic portions were combined and washed with brine, dried (MgSO4), filtered and concentrated in vacuo to provide 139 mg of a yellow oil. The material was purified using radial chromatography by elution with (95:5) hexane:ethyl acetate to provide 119 mg (86%) of product.

Provenance & Evidence