HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → (Z)-2-ethoxy-3-{4-[2-(2-fluoro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-acrylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Chloromethyl-2-(2-fluoro-phenyl)-5-methyl-oxazole | HCID 4441114 | — |
| Reactant | (Z)-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-acrylic acid ethyl ester | HCID 69279871 | — |
| Product | (Z)-2-ethoxy-3-{4-[2-(2-fluoro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-acrylic acid ethyl ester | HCID 69279844 | — |
Reaction Steps
In analogy to the procedure described in example 1 f], (Z)-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-acrylic acid ethyl ester (example 1a c]) was reacted with 4-chloromethyl-2-(2-fluoro-phenyl)-5-methyl-oxazole (example 6 a]) in the presence of cesium carbonate and potassium iodide to yield (Z)-2-ethoxy-3-{4-[2-(2-fluoro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-acrylic acid ethyl ester as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07348349B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-5a9593bc2a9e477eb99475a8d5b89b43 |
| Source note | uspto-grants-2008_03 |