HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-(Benzyloxy)-2-fluorobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 4-(Benzyloxy)-1-bromo-2-fluorobenzene | HCID 22273933 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(Benzyloxy)-2-fluorobenzaldehyde | HCID 12136989 | — |
Reaction Steps
In analogy to the procedure described in example 8 c], 1-bromo-2-fluoro-4-(phenylmethoxy)-benzene was treated with n-BuLi and N,N-dimethylformamide in dry tetrahydrofuran to yield 4-benzyloxy-2-fluoro-benzaldehyde as off-white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07348349B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-1b9b16313fbf417987b0ede5454431d6 |
| Source note | uspto-grants-2008_03 |