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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1394740Generated: October 25, 2026

Triethylsilane → (2S)-3-(4-benzyloxy-2-trifluoromethyl-phenyl)-2-ethoxy-propionic acid methyl ester

https://huagongshe.com/reaction/1394740

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylsilaneHCID 12052—
Reactant(2S,3R)-3-(4-benzyloxy-2-trifluoromethyl-phenyl)-2-ethoxy-3-hydroxy-propionic acid methyl esterHCID 69280418—
SolventTrifluoroacetic acidHCID 6422—
Product(2S)-3-(4-benzyloxy-2-trifluoromethyl-phenyl)-2-ethoxy-propionic acid methyl esterHCID 69282329—

Reaction Steps

In analogy to the procedure described in example 1 c], (2S,3R)-3-(4-benzyloxy-2-trifluoromethyl-phenyl)-2-ethoxy-3-hydroxy-propionic acid methyl ester was treated with triethylsilane in trifluoroacetic acid to yield (2S)-3-(4-benzyloxy-2-trifluoromethyl-phenyl)-2-ethoxy-propionic acid methyl ester as colorless liquid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07348349B2
Source datasetuspto-grants-2008_03
ORD IDord-c6d9ffbf44ee494a95ff272207e9a867
Source noteuspto-grants-2008_03