HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → HCID 69282188, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 3,5-Dichlorobenzaldehyde | HCID 35746 | — |
| Reactant | 4-(Chloromethyl)-2-(3,5-dichlorophenyl)-5-methyl-1,3-oxazole | HCID 22273912 | — |
| Reactant | [Rac]-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid ethyl ester | HCID 57792490 | — |
| Product | HCID 69282188 | HCID 69282188 | — |
Reaction Steps
In analogy to the procedure described in example 1 f], [rac]-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid ethyl ester was reacted with 4-chloromethyl-2-(3,5-dichloro-phenyl)-5-methyl-oxazole (prepared from 3,5-dichloro-benzaldehyde and diacetyl monoxyme followed by treatment with POCl3 in analogy to the procedures described in examples 2 a] and b]) in the presence of cesium carbonate and potassium iodide to yield [rac]-3-{4-[2-(3,5-dichloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid ethyl ester as colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07348349B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-37e03eda64734e718f079564e745e13d |
| Source note | uspto-grants-2008_03 |