反应详情

10% Palladium on carbon (70 mg, 0.07 mmol) was added to a solution of 7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxamide, 13-cyclohexyl-N10-[(dimethylamino)sulfonyl]-N6-(2-hydroxyethyl)-3-methoxy-N6-methyl- (64 mg, 0.11 mmol) in MeOH (3 mL) and the reaction mixture was vacuum flushed with nitrogen (3×) and then with hydrogen (3×). The reaction was stirred under a balloon of hydrogen overnight, filtered through a pad of celite and concentrated to yield 5H-indolo[2,1-a][2]benzazepine-6,10-dicarboxamide, 13-cyclohexyl-N10-[(dimethylamino)sulfonyl]-6,7-dihydro-N6-(2-hydroxyethyl)-3-methoxy-N6-methyl-(50 mg, 0.08 mmol, 78%) as a yellow solid. Mixture of atrope diasteromers:

1. customflushed with nitrogen (3×)
2. filtrationfiltered through a pad of celite
3. concentrationconcentrated