HCID 68896195, compound → HCID 68896125, compound

Participants

Reaction Steps

A solution of 20-3 (0.78 g, 2.7 mmol) and tricyclohexylphosphine[1,3-bis(2,4,6-trinmethylphenyl)-4,5-dihydroimidazol-2-ylidene][benylidine]ruthenium (IV)dichloroide (0.04 g, 0.05 mmol) in CH2Cl2 (500 mL) was stirred 1 hour. at 40° C. under N2. The reaction mixture was concentrated under reduced pressure and purified by flash column chromotography (SiO2, O-30% EtOAc/Hexanes gradient) to give tert-butyl 2-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxylate, 20-4. 1H NMR (300 MHz, CDCl3) δ 7.25 (m, 5H), 5.79 (m, 1H), 5.58 (m, 1H), 4.32 (m, 1H), 4.43 (m, 1H), 1.8 (s, 3H), 1.5 (s, 9H); LRMS m/z (M+H) 260.1 found, 260.2 required.

Provenance & Evidence