Ethylamine → HCID 58641450, compound

Participants

Reaction Steps

A solution of ethyl ({(1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethyl}oxy)acetate (40-1, 16 mg, 0.036 mmol) and ethylamine (10 equiv) in methanol (1 mL) was heated in a sealable tube at 75 deg C. for 20 h. The reaction mixture was concentrated, then purified by reverse-phase liquid chromatography (acetonitrile/H2O with 0.1% TFA present) to provide 2-({(1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethyl}oxy)-N-ethylacetamide (40-2) as a light yellow oil. LRMS m/z (M+H) 441.5 found, 441.5 required.

Provenance & Evidence