Ethanol → HCID 58641201, compound

Participants

Reaction Conditions

Reaction Steps

A solution of {(1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethyl}amine (16-7, 100 mg, 0.282 mmol, 1 equiv) and methyl acrylate (0.076 mL, 0.85 mmol, 3.0 equiv) in a 1:1 mixture of ethanol and dioxane (10 mL) was heated at 85° C. for 20 h. The reaction mixture was concentrated and the residue was purified by flash column chromatography (100% EtOAc) to provide methyl N-{(1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethyl}-β-alaninate (41-1) as a colorless oil that solidified to a white solid over time. LRMS m/z (M+H) 441.4 found, 441.2 required.

Provenance & Evidence