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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1394965Generated: October 25, 2026

p-Bromoacetophenone → HCID 123439274, compound

https://huagongshe.com/reaction/1394965

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-BromoacetophenoneHCID 7466—
Reactant4-(tert-Butoxycarbonyl)morpholine-3-carboxylic acidHCID 2760133—
ReagentCesium carbonateHCID 10796—
Catalyst4,4'-Di-tert-butyl-2,2'-bipyridylHCID 4249187—
CatalystDichloronickel;1,2-dimethoxyethaneHCID 15773433—
CatalystHCID 178441129HCID 178441129—
SolventDimethylformamideHCID 6228—
ProductHCID 123439274HCID 12343927461%

Reaction Conditions

Temperature23 °C

Reaction Steps

Prior to irradiation, the reaction mixture was degassed by bubbling argon for 20 minutes

Provenance & Evidence

DOI10.1126/science.1255525
Source datasetCoupling of α-carboxyl sp3-carbons with aryl halides
ORD IDord-5a3239d982264f8c8dc20d57d17e3036
Source noteCoupling of α-carboxyl sp3-carbons with aryl halides