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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1394971Generated: November 1, 2026

p-Bromoacetophenone → HCID 84662635, compound

https://huagongshe.com/reaction/1394971

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-BromoacetophenoneHCID 7466—
Reactant(+-)-Tetrahydro-2-furoic acidHCID 86079—
ReagentCesium carbonateHCID 10796—
Catalyst4,4'-Di-tert-butyl-2,2'-bipyridylHCID 4249187—
CatalystDichloronickel;1,2-dimethoxyethaneHCID 15773433—
CatalystHCID 178441129HCID 178441129—
SolventDimethylformamideHCID 6228—
ProductHCID 84662635HCID 8466263582%

Reaction Conditions

Temperature23 °C

Reaction Steps

Prior to irradiation, the reaction mixture was degassed by bubbling argon for 20 minutes

Provenance & Evidence

DOI10.1126/science.1255525
Source datasetCoupling of α-carboxyl sp3-carbons with aryl halides
ORD IDord-b1a9540efa8a4ab1b9ae318a0d9c0627
Source noteCoupling of α-carboxyl sp3-carbons with aryl halides