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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1394972Generated: November 2, 2026

4-Iodotoluene → HCID 3558444, compound

https://huagongshe.com/reaction/1394972

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-IodotolueneHCID 12207—
Reactant1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acidHCID 268472—
ReagentCesium carbonateHCID 10796—
Catalyst4,4'-Di-tert-butyl-2,2'-bipyridylHCID 4249187—
CatalystDichloronickel;1,2-dimethoxyethaneHCID 15773433—
CatalystHCID 178441129HCID 178441129—
SolventDimethylformamideHCID 6228—
ProductHCID 3558444HCID 355844478%

Reaction Conditions

Temperature23 °C

Reaction Steps

Prior to irradiation, the reaction mixture was degassed by bubbling argon for 20 minutes

Provenance & Evidence

DOI10.1126/science.1255525
Source datasetCoupling of α-carboxyl sp3-carbons with aryl halides
ORD IDord-42e2098904ab491e9a348d65f0dddb47
Source noteCoupling of α-carboxyl sp3-carbons with aryl halides