HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1394977Generated: November 2, 2026
4-Bromobenzoic acid → 4-[1-(tert-Butoxycarbonyl)pyrrolidin-2-yl]benzoic acid
https://huagongshe.com/reaction/1394977
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Bromobenzoic acid | HCID 11464 | — |
| Reactant | 1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid | HCID 268472 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | 4,4'-Di-tert-butyl-2,2'-bipyridyl | HCID 4249187 | — |
| Catalyst | Dichloronickel;1,2-dimethoxyethane | HCID 15773433 | — |
| Catalyst | HCID 178441129 | HCID 178441129 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-[1-(tert-Butoxycarbonyl)pyrrolidin-2-yl]benzoic acid | HCID 45073985 | 90% |
Reaction Steps
Prior to irradiation, the reaction mixture was degassed by bubbling argon for 20 minutes
Provenance & Evidence
| DOI | 10.1126/science.1255525 |
|---|
| Source dataset | Coupling of α-carboxyl sp3-carbons with aryl halides |
|---|
| ORD ID | ord-ded757113ab1450b9af53f6f08563982 |
|---|
| Source note | Coupling of α-carboxyl sp3-carbons with aryl halides |
|---|
