HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1394980Generated: November 2, 2026
Benzene, 1-bromo-4-(trifluoromethyl)- → HCID 126492163, compound
https://huagongshe.com/reaction/1394980
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzene, 1-bromo-4-(trifluoromethyl)- | HCID 67872 | — |
| Reactant | 1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid | HCID 268472 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | 4,4'-Di-tert-butyl-2,2'-bipyridyl | HCID 4249187 | — |
| Catalyst | Dichloronickel;1,2-dimethoxyethane | HCID 15773433 | — |
| Catalyst | HCID 178441129 | HCID 178441129 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 126492163 | HCID 126492163 | 88% |
Reaction Steps
Prior to irradiation, the reaction mixture was degassed by bubbling argon for 20 minutes
Provenance & Evidence
| DOI | 10.1126/science.1255525 |
|---|
| Source dataset | Coupling of α-carboxyl sp3-carbons with aryl halides |
|---|
| ORD ID | ord-91d90a16b6d748dd994d6e66921b1514 |
|---|
| Source note | Coupling of α-carboxyl sp3-carbons with aryl halides |
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