HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1394982Generated: November 2, 2026
1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid → HCID 123421339, compound
https://huagongshe.com/reaction/1394982
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid | HCID 268472 | — |
| Reactant | 5-Bromo-2-(trifluoromethyl)pyridine | HCID 2761197 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | 4,4'-Di-tert-butyl-2,2'-bipyridyl | HCID 4249187 | — |
| Catalyst | Dichloronickel;1,2-dimethoxyethane | HCID 15773433 | — |
| Catalyst | HCID 178441129 | HCID 178441129 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 123421339 | HCID 123421339 | 82% |
Reaction Steps
Prior to irradiation, the reaction mixture was degassed by bubbling argon for 20 minutes
Provenance & Evidence
| DOI | 10.1126/science.1255525 |
|---|
| Source dataset | Coupling of α-carboxyl sp3-carbons with aryl halides |
|---|
| ORD ID | ord-aec9d01590b046a4bee2b2a86f3fd5e0 |
|---|
| Source note | Coupling of α-carboxyl sp3-carbons with aryl halides |
|---|
