3-Pentanamine → HCID 20341001, compound

HRID 1394987Notes

Reaction equation

HRID 1394987 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH2:10][O:11][CH3:12])[C:5]([N+:13]([O-:15])=[O:14])=[C:4]([CH3:16])[N:3]=1.[CH2:17]([CH:19]([NH2:22])[CH2:20][CH3:21])[CH3:18]>C1(C)C=CC=CC=1>[CH2:17]([CH:19]([NH:22][C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH2:10][O:11][CH3:12])[C:5]([N+:13]([O-:15])=[O:14])=[C:4]([CH3:16])[N:3]=1)[CH2:20][CH3:21])[CH3:18]

Participants

4

Reactant 2

HCID 120193-PentanamineHCID 128692-Chloro-4-(methoxymethyl)-6-methyl-5-nitro-3-pyridinecarbonitrile

Product 1

HCID 20341001HCID 20341001, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
50 °C

Procedure

2-Chloro-3-cyano-4-methoxymethyl-5-nitro-6-methylpyridine (4.8 grams, 0.02 mole), 1-ethylpropylamine (3.6 grams, 0.04 mole) and 100 ml of toluene were charged into a glass reaction vessel fitted with a stirrer, thermometer and condenser. The reaction mixture was stirred and heated to 50° C. for 34 hours. It was then filtered and the solvent stripped off under reduced pressure to yield the desired product 2-(1-ethylpropylamino)-3-cyano-4-methoxymethyl-5-nitro-6-methylpyridine as a brown solid having a melting point of 74°-76° C.

Workup

  1. customfitted with a stirrer
  2. filtrationIt was then filtered

Sources & evidence

ORD record
ord-a971c8c1140f4632a5559d57138be601
Source dataset
uspto-grants-1980_05
Patent number
US04201568

Reaction notes

Loading…