Phosphorus sulfide (P2S5) → HCID 88786584, compound

Participants

Reaction Steps

(a) 0.1 Mol=35.8 gm of 7-bromo-5-(o-chlorophenyl)-thieno-[2,3-e]-4,1-oxazepinone were heated with 350 ml of diglyme, 24 gm of P2S5 and 19 gm of NaHCO3 for 30 minutes at 60° C. Subsequently, the reaction mixture was poured over about 1 liter of ice water, whereby a crystalline precipitate was formed, which was suction-filtered off, washed with water and dried. 37 gm=99% of theory of 7-bromo-5-(o-chlorophenyl)-thieno-[2,3-e]-4,1-oxazepine-2-thione were obtained M.p. from 200° C. (decomp.).

Provenance & Evidence