HCID 12383924, compound → HCID 3049083, compound

HRID 1395026Notes

Reaction equation

HRID 1395026 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([C:10]([NH:17][CH2:18][CH2:19][C:20](OC)=[O:21])([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13])[CH2:8][CH3:9]>CCOCC>[OH:21][CH2:20][CH2:19][CH2:18][NH:17][C:10]([CH2:7][CH2:8][CH3:9])([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 12383924HCID 12383924, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 3049083HCID 3049083, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Into a 500-ml three-necked flask fitted with a mechanical stirrer, a condenser and a dropping-funnel were introduced 3.8 g (0.17 mol) of lithium aluminium hydride and 130 ml of dry ether. To this mixture were slowly added 12.2 g (0.05 mol) of methyl 3-(1,1-di-n-propyl-n-butylamino)-propanoate, prepared as previously described. The reaction medium was heated under reflux for 12 hours and then hydrolyzed. The precipitate which formed was washed with ether, the ether was evaporated off and the oil so obtained was distilled.

Workup

  1. customInto a 500-ml three-necked flask fitted with a mechanical stirrer, a condenser and a dropping-funnel
  2. customprepared
  3. temperatureThe reaction medium was heated
  4. temperatureunder reflux for 12 hours
  5. customThe precipitate which formed
  6. washwas washed with ether
  7. customthe ether was evaporated off
  8. customthe oil so obtained
  9. distillationwas distilled

Sources & evidence

ORD record
ord-e3f7b5adca3346dc958eb98a8ea8f75a
Source dataset
uspto-grants-1980_05
Patent number
US04201725

Reaction notes

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