HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 20341477, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-Chloro-6-hydroxybenzaldehyde | HCID 528393 | — |
| Reactant | Propanedioic acid, monoethyl ester | HCID 3595298 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 20341477 | HCID 20341477 | 58% |
Reaction Steps
15 g (0.0958 mole) of 2-chloro-6-hydroxy-benzaldehyde, 16.7 g (0.105 mole) ethyl malonate, 40 mL ethanol, 0.6 mL piperidine and 0.1 mL acetic acid are refluxed for 5 hours. After cooling the resultant product is dried. After drying, 14 g of ethyl 5-chlorocoumarin-3-carboxylate are obtained. (Yield=58%). Melting pointG =142°-144° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04201783 |
| Source dataset | uspto-grants-1980_05 |
| ORD ID | ord-2c51f9e1474343b4a430918251857d7d |
| Source note | uspto-grants-1980_05 |