Isobutyraldehyde → 71326-11-9

HRID 1395063Notes

Reaction equation

HRID 1395063 reaction equation
[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH2:6].[CH:8](=O)[CH:9]([CH3:11])[CH3:10]>C1C=CC=CC=1.[Ni]>[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][N:6]=[CH:8][CH:9]([CH3:11])[CH3:10]

Participants

5

Reactant 2

HCID 6561IsobutyraldehydeHCID 7993N,N-Dimethyl-1,3-propanediamine

Product 1

HCID 2034159871326-11-9

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 241BenzeneSolvent2×

Procedure

A solution of N,N-dimethyl-N'-isobutylidene-1,3-diaminopropane in benzene is prepared by reacting 92 g of 3-dimethylamino-1-propylamine with 65 g of isobutyraldehyde in 200 ml of benzene by separating off the water of reaction azeotropically. This solution is hydrogenated in an autoclave at 90° C. and 125 atmospheres in the presence of 14 g of Raney nickel. Working up by distillation yields 95.6 g of pure product with a boiling point of 75° C./14 mm Hg.

Workup

  1. customby separating off
  2. customthe water of reaction azeotropically
  3. customis hydrogenated in an autoclave at 90° C.
  4. distillationWorking up by distillation

Sources & evidence

ORD record
ord-af93bb06b49d4f5ca4f95222f101c5da
Source dataset
uspto-grants-1980_05
Patent number
US04201854

Reaction notes

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