Toluene → 2-Methylindolizine-3-carbonyl chloride

HRID 1395091Notes

Reaction equation

HRID 1395091 reaction equation
[C:1]([Cl:4])(Cl)=[O:2].C[C:6]1[CH:7]=[CH:8][N:9]2[C:14]=1[CH:13]=[CH:12][CH:11]=[CH:10]2.[C:15]1(C)C=CC=CC=1>>[CH3:15][C:7]1[CH:6]=[C:14]2[N:9]([C:8]=1[C:1]([Cl:4])=[O:2])[CH:10]=[CH:11][CH:12]=[CH:13]2

Participants

4

Reactant 3

HCID 1140Toluene2×HCID 6371PhosgeneHCID 582636HCID 582636, compound

Product 1

HCID 203401302-Methylindolizine-3-carbonyl chloride

Procedure

A solution of 99 g of phosgene (1 mole) in 800 ml of anhydrous toluene was cooled beneath 15° C. While the reaction mixture was cooled and stirred a solution of 131 g of methylindolizine (1 mole) in 475 ml of anhydrous toluene was added dropwise. The reaction mixture was kept overnight and the residue formed was sucked off.

Workup

  1. temperatureWhile the reaction mixture was cooled
  2. additionwas added dropwise
  3. customthe residue formed

Sources & evidence

ORD record
ord-5d15fa7eca9b4e8faf04d7a985810b1f
Source dataset
uspto-grants-1980_05
Patent number
US04202697

Reaction notes

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