Dimethyl Sulfate → HCID 178493578, compound

Participants

Reaction Conditions

Reaction Steps

76 g (0.6 mol) of dimethyl sulphate were added dropwise to a solution of 76 g (0.5 mol) of 2-cyclopropyl-4,6-dihydroxy-pyrimidine in 250 ml of 2 N sodium hydroxide solution at 50° C. The pH value of the reaction solution was kept at 8 to 8.2 by simultaneously adding 2 N sodium hydroxide solution. The mixture was then stirred at 50° C. for a further 2 hours, control of the pH being continued. The mixture was then cooled to 0° C. and the product which had precipitated was filtered off. 33 g (40% of theory) of 2-cyclopropyl-4-hydroxy-6-methoxy-pyrimidine were obtained in this manner in the form of colorless crystals with a melting point of 186° C.

Provenance & Evidence