反应详情

4.0 g (120 mmol) of anhydrous hydrazine and 2.3 g (12 mmol) of 1-chloromethyladamantane were introduced into a sealable tube under nitrogen atmosphere. The tube was sealed and heated at 150° for 16 hours. After cooling to room temperature the contents were suspended in methanol, treated with a solution 0.5 g of sodium hydroxide in 1.5 ml of water, and the volatiles removed in vacuo. The resulting solid was extracted with ether and the solution dried with magnesium sulfate and treated with hydrogen chloride to give 1 g of the title compound (38% yield).

1. customThe tube was sealed
2. temperatureheated at 150° for 16 hours
3. customthe volatiles removed in vacuo
4. extractionThe resulting solid was extracted with ether
5. dry with materialthe solution dried with magnesium sulfate
6. additiontreated with hydrogen chloride