Sodium Hydroxide → HCID 57321997, compound

Participants

Reaction Conditions

Reaction Steps

110 G. of a 70% sodium dihydro-bis-(2-methoxyethoxy)-aluminate solution in toluene are added dropwise at 25°-30° C. over a period of 90 minutes to a solution of 85 g. of 3-(p-tert.-amyl-phenyl)-2,3-dimethyl-acrylic acid ethyl ester in 400 ml. of absolute toluene and the mixture is subsequently warmed at 40° C. for 2 hours. The mixture is then cooled down to -10° C. and treated dropwise over 300 ml. of 2 N sodium hydroxide. The toluene phase is separated and the aqueous-alkaline phase is back-extracted twice with 300 ml. of toluene. The combined toluene phases are washed neutral with water, dried over sodium sulfate and evaporated. By distillation there is obtained pure 3-(p-tert.-amyl-phenyl)-2,3-dimethyl-allyl alcohol; nD20 =1.5311.

Provenance & Evidence