Butylamine → HCID 85916609, compound

HRID 1395226Notes

Reaction equation

HRID 1395226 reaction equation
Cl[C:2]1[C:7]2[CH:8]=[N:9][C:10]3[N:14]([CH2:15][CH3:16])[N:13]=[CH:12][C:11]=3[C:6]=2[N:5]2[N:17]=[CH:18][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:4]2[N:3]=1.[CH2:25]([NH2:29])[CH2:26][CH2:27][CH3:28]>>[CH2:25]([NH:29][C:2]1[C:7]2[CH:8]=[N:9][C:10]3[N:14]([CH2:15][CH3:16])[N:13]=[CH:12][C:11]=3[C:6]=2[N:5]2[N:17]=[CH:18][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:4]2[N:3]=1)[CH2:26][CH2:27][CH3:28]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 85916602HCID 85916602, compound

Product 1

HCID 85916609HCID 85916609, compoundYield 84%

Procedure

3.5 g of 5-chloro-8-ethyl-8H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidine-3-carboxylic acid, ethyl ester (0.01 mol) and 7.3 g of n-butylamine are refluxed together with 30 ml of alcohol with stirring for 8 hours. The solution is evaporated to dryness and the residue treated with water and filtered off. Recrystallization from ethyl acetate yields 3.2 g (84%) of 5-(n-butylamino)-8-ethyl-8H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidine-3-carboxylic acid, ethyl ester; m.p. 275°-277°.

Workup

  1. customThe solution is evaporated to dryness
  2. additionthe residue treated with water
  3. filtrationfiltered off
  4. customRecrystallization from ethyl acetate

Sources & evidence

ORD record
ord-6127be74e2e547c1b4926b29e2d795b6
Source dataset
uspto-grants-1980_05
Patent number
US04202899

Reaction notes

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