5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 136044000, compound

HRID 1395382Notes

Reaction equation

HRID 1395382 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH2:14])=[CH:7][CH:6]=1)[CH3:3].[CH2:15]([NH:19][C:20](=[N:23][C:24]#[N:25])SC)[C:16]#[C:17][CH3:18]>>[C:24]([NH:23][C:20]([NH:19][CH2:15][C:16]#[C:17][CH3:18])=[N:14][CH2:13][CH2:12][S:11][CH2:10][C:8]1[O:9][C:5]([CH2:4][N:2]([CH3:1])[CH3:3])=[CH:6][CH:7]=1)#[N:25]

Participants

3

Reactant 2

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 178449194HCID 178449194, compound

Product 1

HCID 136044000HCID 136044000, compound

Procedure

2-[(5-Dimethylaminomethyl-2-furyl)methylthio]ethylamine is reacted in a non-reactive solvent with about an equimolar amount of N-(2-butyn-1-yl)-N'-cyano-S-methylisothiourea [prepared according to the procedure described in U.S. Pat. No. 4,112,234, the complete disclosure of which is incorporated herein by reference] and, after workup and chromatography, the title product is produced.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-39b90ec29f7747ca839ef4f7da297680
Source dataset
uspto-grants-1980_05
Patent number
US04203909

Reaction notes

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