Formaldehyde → 2-{(5-{[N-methyl-N-propargylamino]methyl}-2-furyl)methylthio}ethylamine

Participants

Reaction Steps

The reaction of furfuryl alcohol and N-methylpropargylamine hydrochloride with paraformaldehyde according to the general procedure of J. Chem. Soc., 4728 (1958), and treatment of the product with cysteamine hydrochloride followed by neutralization, produces 2-{(5-{[N-methyl-N-propargylamino]methyl}-2-furyl)methylthio}ethylamine. When the latter product is reacted with 1,1-bis(methylthio)-2-nitroethylene and then with propargylamine according to the general procedure of Example 1, the title compound is produced.

Provenance & Evidence