Potassium Iodide → HCID 20339424, compound

Participants

Reaction Steps

A solution of 6.1 g. (0.03 mole) of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one, 6.3 g. (0.04 mole) of 3-(4-pyridyl)-1-chloropropane, 10 g. of potassium carbonate, 5 g. of potassium iodide and 0.5 ml. of triethylamine was stirred and refluxed in 200 ml. of acetone for 48 hours, then cooled and filtered. The solvent was removed, and the residue was dissolved in ethanol-ether and treated with dry hydrogen chloride saturated ether. The product hyrochloride was filtered and recrystallized two times from methanol. Dried at 100° C./0.1 mm. Yield: 6.2 g. (44%) as the dihydrochloride salt, m.p. 188°-190° C.

Provenance & Evidence