Hydrochloric Acid → HCID 20339421, compound

Participants

Reaction Steps

A solution of 4.2 g. (0.02 mole) of 8-fluoro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one, 7 g. (0.04 mole) of 4-(4-pyridyl)-1-chlorobutane, 8 g. of potassium carbonate, 5 g. of potassium iodide, and 0.5 ml. of triethylamine was stirred and refluxed in 200 ml. of acetone for 72 hours, cooled and filtered. The solvent was removed and the residue was dissolved in methylene chloride. This solution was washed with water and brine, dried over magnesium sulfate and filtered. The solvent was removed and the residue was chromatographed on 500 g. of Silicar, CC-7. Fractions eluted with 10% methanol in ethyl acetate afforded the product as a free base. This free base was dissolved in ethanol and treated with dry hydrogen chloride saturated ether. The product hydrochloride was filtered and recrystallized from methanol to give 2.3 g. of the title compound as the dihydrochloride salt, m.p. 262°-264° C.

Provenance & Evidence