反应详情

To about 50 milliliters of ethanol is added 3.63 grams (10 millimoles) of [2-(4-benzhydrylpiperidino)-2-oxoethoxy]acetic acid (prepared as described in Example V) and 200 milligrams of p-toluenesulfonic acid and the mixture refluxed for about four hours whereupon a reaction takes place with the formation in the reaction mixture of the desired ester product as confirmed by chromatographic analysis. The reaction mixture is subjected to reduced pressure to evaporate the ethanol and to obtain a product residue which is then dissolved in dichloromethane. The dichloromethane solution is first washed with aqueous bicarbonate solution, then dried over potassium carbonate and finally evaporated under reduced pressure to recover an ethyl [2-(4-benzhydrylpiperidino)-2-oxoethoxy]acetate product as residue. The ester product which may be further purified by distillation under reduced pressure has a molecular weight of 391.5.

1. temperaturethe mixture refluxed for about four hours whereupon a reaction
2. customto evaporate the ethanol
3. customto obtain a product residue which
4. washThe dichloromethane solution is first washed with aqueous bicarbonate solution
5. dry with materialdried over potassium carbonate
6. customfinally evaporated under reduced pressure
7. customto recover an ethyl [2-(4-benzhydrylpiperidino)-2-oxoethoxy]acetate product as residue
8. distillationThe ester product which may be further purified by distillation under reduced pressure