HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-(2-Dimethylaminoethylamino)-6-dimethylaminomethylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | [(6-Chloropyridin-2-yl)methyl]dimethylamine | HCID 20434272 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-(2-Dimethylaminoethylamino)-6-dimethylaminomethylpyridine | HCID 20339527 | 35.4% |
Reaction Steps
2-Chloro-6-dimethylaminomethylpyridine (14 g., 0.0825 mole) and unsym-dimethylethylenediamine (21.8 g, 0.248 mole) in 10 ml of pyridine are heated at 180° for 8 hours in a bomb. The dark reaction mixture is stirred over 20 g of solid sodium hydroxide for 1 hour on a steam bath. Then the mixture is filtered. Distillation of the filtrate gives 6.5 g of product, b.p. 110°-11° at 0.1 mm, nD25 1.5287.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04203988 |
| Source dataset | uspto-grants-1980_05 |
| ORD ID | ord-2118240aacf4412685a1411ec7e1eef5 |
| Source note | uspto-grants-1980_05 |