Dimethylamine → HCID 20339506, compound

HRID 1395550Notes

Reaction equation

HRID 1395550 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][C:9](=[O:13])OCC)[CH:5]=[CH:4][C:3]=1[Cl:14].[CH3:15][NH:16][CH3:17]>C(O)C>[CH3:15][N:16]([CH3:17])[C:9]([NH:8][C:6]1[CH:5]=[CH:4][C:3]([Cl:14])=[C:2]([NH2:1])[N:7]=1)=[O:13]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 20339459HCID 20339459, compound

Product 1

HCID 20339506HCID 20339506, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl N-(6-amino-5-chloro-2-pyridyl)carbamate (64.7 g., 0.3 mole), dimethylamine (45 g., 1.0 mole) and 300 ml. of ethanol is heated at 120° C. for 24 hours in a pressure vessel. The reaction mixture is then concentrated in vacuo and 68 g. of brown solid is obtained. Recrystallization from n-butyl chloride gives pure material, m.p. 139°-141°

Workup

  1. concentrationThe reaction mixture is then concentrated in vacuo and 68 g
  2. customof brown solid is obtained
  3. customRecrystallization from n-butyl chloride
  4. customgives pure material, m.p. 139°-141°

Sources & evidence

ORD record
ord-06621220828144bea5bd43aa74768b23
Source dataset
uspto-grants-1980_05
Patent number
US04203988

Reaction notes

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