HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Di-tert-butyl-4-hydroxybenzaldehyde → HCID 136263227, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Di-tert-butyl-4-hydroxybenzaldehyde | HCID 73219 | — |
| Reactant | (6R,7R)-Benzhydryl 7-amino-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | HCID 12873516 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 136263227 | HCID 136263227 | — |
Reaction Steps
A solution of diphenylmethyl 7β-amino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate (9.89 g) and 3,5-di-t-butyl-4-hydroxybenzaldehyde (5.62 g) in a mixture of benzene (160 ml) and dichloromethane (40 ml) is refluxed for 1 hour in the presence of a molecular sieve to give a solution of diphenylmethyl 7β-(3,5-di-t-butyl-4-hydroxy-benzylidene)amino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04203982 |
| Source dataset | uspto-grants-1980_05 |
| ORD ID | ord-294868dadeb24d97ae49166d03edb0e5 |
| Source note | uspto-grants-1980_05 |