Sodium Hydroxide → HCID 12788636, compound

HRID 1395588Notes

Reaction equation

HRID 1395588 reaction equation
C([O:3][C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH:12]1[N:16]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:15](=[O:28])[NH:14][C:13]1=[O:29])=[O:5])C.[OH-].[Na+]>>[C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH:12]1[N:16]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:15](=[O:28])[NH:14][C:13]1=[O:29])([OH:5])=[O:3]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 20340031HCID 20340031, compound

Product 1

HCID 12788636HCID 12788636, compound

Procedure

The foregoing ester (4.0 g) was hydrolysed by treatment with dilute sodium hydroxide solution and the product was purified by chromatography on silica gel, to give 5-(6-carboxyhexyl)-1-(5-phenylpentyl)hydantoin crystallising from ethyl acetate-light petroleum (b.p. 60°-80° C.) in colourless prismatic needles, m.p. 90°-92° C.

Workup

  1. customthe product was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-b673a5fd89c0480fa8afbd4246462eaf
Source dataset
uspto-grants-1980_05
Patent number
US04204068

Reaction notes

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