反应详情

A mixture of the above ester (0.46 g), potassium hydroxide (2.5 mmol), 3 ml methanol and 0.5 ml water is stirred at about 45° overnight. Methanol is removed by evaporation and then 5% NaOH-ether is added. After adjusting to about pH 3 by addition of dilute HCl, the mixture is extracted with ether. The ether phase is washed with water and brine, dried over sodium sulfate, and solvent evaporated to yield 2-isopropyl-4-(4-fluorophenyl)-3-butenoic acid.

1. customMethanol is removed by evaporation
2. addition5% NaOH-ether is added
3. additionAfter adjusting to about pH 3 by addition of dilute HCl
4. extractionthe mixture is extracted with ether
5. washThe ether phase is washed with water and brine
6. dry with materialdried over sodium sulfate, and solvent
7. customevaporated