Phosphorus tribromide → HCID 54036814, compound

HRID 1395615Notes

Reaction equation

HRID 1395615 reaction equation
[F:1][C:2](=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3]O.P(Br)(Br)[Br:13]>CCOCC>[F:1][C:2](=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][Br:13]

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 592349HCID 592349, compound

Product 1

HCID 54036814HCID 54036814, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To the above alcohol (1.27 g, 8.34 mmol) in 50 ml ether at 0° under nitrogen is added phosphorus tribromide (2.25 g, 8.31 mmol). The reaction mixture is stirred about 2 hours as followed by TLC. The reaction mixture is worked up by pouring onto ice, then extracting with ether/water. The aqueous layer is extracted with ether. The combined ether phases are washed with water and brine, dried (Na2SO4) and evaporated to yield 2-fluoro-3-phenyl-2-propen-1-yl bromide.

Workup

  1. additionby pouring onto ice
  2. extractionextracting with ether/water
  3. extractionThe aqueous layer is extracted with ether
  4. washThe combined ether phases are washed with water and brine
  5. dry with materialdried (Na2SO4)
  6. customevaporated

Sources & evidence

ORD record
ord-ebe6b56975fe4a1587689dd617e81bec
Source dataset
uspto-grants-1980_05
Patent number
US04204071

Reaction notes

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