Ammonia → Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1)

HRID 1395619Notes

Reaction equation

HRID 1395619 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[NH3:11].O>C(O)C>[ClH:1].[NH2:11][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 962WaterHCID 107572-Chloroacetophenone

Product 1

HCID 2723597Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1)Yield 20%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

15.5 g of ω-chloroacetophenone are dissolved while stirring in 200 ml of ethanol saturated with ammonia. After standing overnight, the orange-coloured solution is poured onto 500 ml of water. The precipitating oil is separated off and taken up with 80 ml of 20% hydrochloric acid Concentration give 5 g (20% yield) of ω-aminoacetophenone hydrochloride.

Workup

  1. customThe precipitating oil is separated off
  2. concentrationtaken up with 80 ml of 20% hydrochloric acid Concentration

Sources & evidence

ORD record
ord-63d105509ac0473a958c9aff87debd6f
Source dataset
uspto-grants-1980_05
Patent number
US04204867

Reaction notes

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